We like things that move – at the nanoscale.
At the Nano Dynamics Lab, we are fascinated by the molecular dynamics found in biomolecules, and we strive to investigate them experimentally at the single-molecule level using cutting-edge nanopore & smFRET techniques.
Proteins are the molecular makers in our body. They perform all vital cellular functions to maintain life as we know it: cell growth & division, genome replication & repair, energy harvesting & conversion, self-defence & attack, environmental sensing & reaction to it, etc. etc. To do this all, proteins adopt different 3D conformations and change their interaction partners dynamically. However, these essential molecular dynamics are challenging to observe and dissect experimentally, because they usually happen unsynchronized in a large molecular ensemble.
To tackle this, in the NanoDynamicsLab, we use & develop innovative single-molecule techniques to gain quantitative insight into biomolecular dynamics, in order to understand the molecular basis of protein function and also malfunction leading to disease. In particular, we are fascinated by how functional dynamics arise from specific structural elements (protein domains, or even single atoms) in the context of diverse energy sources, including thermal and chemical energy, light, ion gradients etc. And we aim to understand and alter such nanoscale processes in a controlled way.
27/05/2022. [Cash] We are thankful to receive IPM-4 seed funding to study bacterial micro-compartments together with S. Kengen & C. Patinios at WUR/Microbio.
16/05/2022. The FRET Satellite Meeting following MAF2022 is open for registration! Talk abstracts by early-career researchers are requested with a deadline of 05/06/2022. Don't miss! Preliminary program here. See you all in Gothenburg, in September!
15/03/2022. [Team] We’re happy to welcome a new group member: Jannick joins us for his MSc thesis to model and produce Hsp90 chimeras and decipher their inner working mechanisms. Welcome, Jannick!
13/05/2022. [Paper] Benjamin’s 1st paper is out now at Nano Research: Can DyeCycling break the photobleaching limit in single-molecule FRET?
06/05/2022. [Team] We have a new Master of Science: Raluca Vintan successfully defended her thesis on biomolecular trapping with nanopores. Congrats, Raluca!
04/05/2022. [Talk] Sonja gives the MNP / BioNano Seminar virtually at the Uni of Leeds. Thank you, George Heath, for the invite and Paolo Actis and many others for the nice discussion.
08/04/2022. [Talk] Sonja speaks at the Dutch Chaperone Meeting. What a great way to get introduced to the local chaperone community. Many thanks, Mark Hipp and Harrie Kampinga, for the organization, the chance to speak, and the warm welcome.
15/03/2022. [Team] We’re happy to welcome two new members: Floor and Ben join us for a BSc thesis on zero-mode waveguides and an internship on pattern recognition, respectively. Welcome!